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| Modelling prognostic capabilities of tumor size : application to colorectal cancer (en Anglais) | |||
Droits : Creative Commons (BY NC) Auteur(s) : RONDEAU Virginie, Université de Bordeaux - Service Audiovisuel et Multimédia Éditeur(s) : Université de Bordeaux - Service Audiovisuel et Multimédia 10-11-2015 Description : Epidemiology and public health In oncology, the international WHO and RECIST criteria have allowed the standardization of tumor response evaluation in order to identify the time of disease progression. These semi-quantitative measurements are often used as endpoints in phase II and phase III trials to study the efficacy of new therapies. However, through categorization of the continuous tumor size, information can be lost and they can be challenged by recently developed methods of modeling biomarkers in a longitudinal way. Thus, it is of interest to compare the predictive ability of cancer progressions based on categorical criteria and quantitative measures of tumor size (left-censored due to detection limit problems) and/or appearance of new lesions on overall survival. We propose a joint model for a simultaneous analysis of three types of data: longitudinal marker, recurrent events and a terminal event. A simulation study is performed and shows that the proposed trivariate model is appropriate for the practical use. We suggest statistical tools that evaluate predictive accuracy for joint models to compare our model to models based on categorical criteria and their components. We apply the model to a randomized phase III clinical trial of metastatic colorectal cancer, conducted by the Fédération Francophone de Cancérologie Digestive (FFCD 2000-05 trial), which assigned 410 patients to two therapeutic strategies with multiple successive chemotherapy regimens. Cette présentation a été donnée dans le cadre du BRIO SIRIC scientific day 3 organisé annuellement par le SIRIC BRIO et qui a pour but de réunir tous les acteurs du SIRIC BRIO et plus largement de la cancérologie à Bordeaux. Mots-clés libres : cancer,Oncologie,Thérapie,Recherche | TECHNIQUE Type : image en mouvement Format : video/x-flv Source(s) : rtmpt://fms2.cerimes.fr:80/vod/groupe_dcam/modelling.prognostic.capabilities.of.tumor.size.application.to.colorectal.cancer_19676/brio.siric_virginie.rondeau_mdeb.mp4 | ||
Entrepôt d'origine : Canal-u.fr Identifiant : oai:canal-u.fr:19676 Type de ressource : Ressource documentaire | |||
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Ressource pédagogique
| Modelling prognostic capabilities of tumor size : application to colorectal cancer (en Anglais) | |||||||||
Identifiant de la fiche : 19676 Schéma de la métadonnée : LOMv1.0, LOMFRv1.0 Droits : libre de droits, gratuit Droits réservés à l'éditeur et aux auteurs. Creative Commons (BY NC) Auteur(s) : RONDEAU VIRGINIE Éditeur(s) : Université de Bordeaux - Service Audiovisuel et Multimédia, Université de Bordeaux - Service Audiovisuel et Multimédia, Université de Bordeaux - Service Audiovisuel et Multimédia 10-11-2015 Description : Epidemiology and public health In oncology, the international WHO and RECIST criteria have allowed the standardization of tumor response evaluation in order to identify the time of disease progression. These semi-quantitative measurements are often used as endpoints in phase II and phase III trials to study the efficacy of new therapies. However, through categorization of the continuous tumor size, information can be lost and they can be challenged by recently developed methods of modeling biomarkers in a longitudinal way. Thus, it is of interest to compare the predictive ability of cancer progressions based on categorical criteria and quantitative measures of tumor size (left-censored due to detection limit problems) and/or appearance of new lesions on overall survival. We propose a joint model for a simultaneous analysis of three types of data: longitudinal marker, recurrent events and a terminal event. A simulation study is performed and shows that the proposed trivariate model is appropriate for the practical use. We suggest statistical tools that evaluate predictive accuracy for joint models to compare our model to models based on categorical criteria and their components. We apply the model to a randomized phase III clinical trial of metastatic colorectal cancer, conducted by the Fédération Francophone de Cancérologie Digestive (FFCD 2000-05 trial), which assigned 410 patients to two therapeutic strategies with multiple successive chemotherapy regimens. Cette présentation a été donnée dans le cadre du BRIO SIRIC scientific day 3 organisé annuellement par le SIRIC BRIO et qui a pour but de réunir tous les acteurs du SIRIC BRIO et plus largement de la cancérologie à Bordeaux. Mots-clés libres : cancer, oncologie, thérapie, recherche
| PEDAGOGIQUE Type pédagogique : cours / présentation Niveau : doctorat, enseignement supérieur TECHNIQUE Type de contenu : image en mouvement Format : video/x-flv Taille : 120.17 Mo Durée d'exécution : 20 minutes 21 secondes RELATIONS Cette ressource fait partie de : | ||||||||
Entrepôt d'origine : Canal-u.fr Identifiant : oai:canal-u.fr:19676 Type de ressource : Ressource pédagogique | |||||||||
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